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https://www.hk01.com/世界說/537010/新冠病毒sads-cov不僅感染豬隻-美國研究-恐跨物種傳到人類身上
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｜originally written by Pei-Chi Lo
■確實有此研究，Caitlin E. Edwards等人的確以SADS-CoV的合成形式實驗，發現其有廣泛的宿主範圍並能在人的肺與腸細胞中有效複製。

■報導與研究內容大抵相符，補充細節資訊如下：

①依據上述發現，作者認為此種冠狀病毒有跨物種外溢感染(spillover infection)給人的潛在風險，而非已證實跨物種感染會發生。

②SADS-CoV並非對所有仔豬都有高致死率，剛出生5天以內的仔豬致死率的確約90%，但8天以上的仔豬致死率即下降至5%。

③SADS-CoV、COVID-19的冠狀病毒的確同科(family)但不同屬(Genus)，前者是甲型冠狀病毒屬(alphacoronavirus)，後者是乙型冠狀病毒屬(betacoronavirus)。

References

《PNAS》2020年10月12日刊登的研究全文-Swine acute diarrhea syndrome coronavirus replication in primary human cells reveals potential susceptibility to infection：
https://www.pnas.org/content/early/2020/10/06/2001046117

針對上述研究，北卡羅來納大學教堂山分校的新聞稿說明：
https://www.unc.edu/posts/2020/10/14/swine-coronavirus-shows-potential-to-spread-to-humans/

2018年《Nature》研究提及SADS-CoV對仔豬的疾病致死率，見「Main」段：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094983/

Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin

Cross-species transmission of viruses from wildlife animal reservoirs poses a marked threat to human and animal health[] . Bats have been recognized as one of the most important reservoirs for emergin

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094983/

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