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Pei-Chi Lo mark this message contains misinformation
originally written by Pei-Chi Lo
■標題過於聳動、易誤導:

①這篇文章是基於2020年10月21日布里斯托爾大學團隊發布的預印本論文。

②論文作者透過基因定序和蛋白質分析,認為牛津與阿斯特捷利康公司共同研發的「AZD1222」疫苗在產生大量冠狀病毒刺突蛋白有相當高的準確性,此可解釋為何該疫苗能成功引發強烈免疫反應。

③但須提醒,這是一篇預印本論文,尚未經同儕審查,不應作為既定事實報導;在文章通過審查刊登於正式期刊前,宜謹慎看待其內容。

■無論如何,該疫苗仍在臨床試驗階段:

①AZD1222疫苗曾在臨床試驗受試者有不良反應而暫停,近期經安全性獨立審查後,英國、美國、巴西、南非、日本等國政府皆已允許第三期臨床試驗繼續進行,以確認在大規模受試者中仍有其安全其有效性。

②迄今(2020年11月)試驗仍進行中,疫苗尚未正式核准上市。

References

【預印本論文】

2020年10月21日發布的預印本研究-SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression:
https://www.researchsquare.com/article/rs-94837/v1

針對此預印本,布里斯托爾大學的說明新聞稿:
https://www.bristol.ac.uk/news/2020/october/oxford-covid-19-vaccine-.html

針對此預印本,牛津大學的說明新聞稿:
https://www.research.ox.ac.uk/Article/2020-10-21-oxford-covid-19-vaccine-follows-its-programmed-genetic-instructions-independent-analysis-finds

【疫苗進度】

2020年10月22日牛津大學新聞稿說明疫苗進度:
https://www.research.ox.ac.uk/Article/2020-10-22-global-clinical-trials-of-covid-19-vaccine-resume

WHO COVID-19疫苗專區,「Draft landscape of COVID-19 candidate vaccines」可看候選疫苗各期臨床試驗資料:
https://www.who.int/teams/blueprint/covid-19

assess how often and how accurately the vaccine is copying and using the genetic instructions provided by the Oxford team. These i

SARS-CoV-2 candidate vaccine ChAdOx1 nCoV-19 infection of human cell lines reveals a normal low range of viral backbone gene expression alongside very high levels of SARS-CoV-2 S glycoprotein expression.

Background: ChAdOx1 nCoV-19 is a recombinant adenovirus vaccine candidate against SARS-CoV-2. Although replication defective in normal cells, 28kbp of adenovirus genes are delivered to the cell nucleu

https://www.researchsquare.com/article/rs-94837/v1

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